1,831 research outputs found
Evolution of Cooperation and Coordination in a Dynamically Networked Society
Situations of conflict giving rise to social dilemmas are widespread in
society and game theory is one major way in which they can be investigated.
Starting from the observation that individuals in society interact through
networks of acquaintances, we model the co-evolution of the agents' strategies
and of the social network itself using two prototypical games, the Prisoner's
Dilemma and the Stag Hunt. Allowing agents to dismiss ties and establish new
ones, we find that cooperation and coordination can be achieved through the
self-organization of the social network, a result that is non-trivial,
especially in the Prisoner's Dilemma case. The evolution and stability of
cooperation implies the condensation of agents exploiting particular game
strategies into strong and stable clusters which are more densely connected,
even in the more difficult case of the Prisoner's Dilemma.Comment: 18 pages, 14 figures. to appea
Simulation of Preterm Neonatal Brain Metabolism During Functional Neuronal Activation Using a Computational Model
We present a computational model of metabolism in the preterm neonatal brain. The model has the capacity to mimic haemodynamic and metabolic changes during functional activation and simulate functional near-infrared spectroscopy (fNIRS) data. As an initial test of the model's efficacy, we simulate data obtained from published studies investigating functional activity in preterm neonates. In addition we simulated recently collected data from preterm neonates during visual activation. The model is well able to predict the haemodynamic and metabolic changes from these observations. In particular, we found that changes in cerebral blood flow and blood pressure may account for the observed variability of the magnitude and sign of stimulus-evoked haemodynamic changes reported in preterm infants
The relativistic Sagnac Effect: two derivations
The phase shift due to the Sagnac Effect, for relativistic matter and
electromagnetic beams, counter-propagating in a rotating interferometer, is
deduced using two different approaches. From one hand, we show that the
relativistic law of velocity addition leads to the well known Sagnac time
difference, which is the same independently of the physical nature of the
interfering beams, evidencing in this way the universality of the effect.
Another derivation is based on a formal analogy with the phase shift induced by
the magnetic potential for charged particles travelling in a region where a
constant vector potential is present: this is the so called Aharonov-Bohm
effect. Both derivations are carried out in a fully relativistic context, using
a suitable 1+3 splitting that allows us to recognize and define the space where
electromagnetic and matter waves propagate: this is an extended 3-space, which
we call "relative space". It is recognized as the only space having an actual
physical meaning from an operational point of view, and it is identified as the
'physical space of the rotating platform': the geometry of this space turns out
to be non Euclidean, according to Einstein's early intuition.Comment: 49 pages, LaTeX, 3 EPS figures. Revised (final) version, minor
corrections; to appear in "Relativity in Rotating Frames", ed. G. Rizzi and
M.L. Ruggiero, Kluwer Academic Publishers, Dordrecht, (2003). See also
http://digilander.libero.it/solciclo
Mesoscopic structure conditions the emergence of cooperation on social networks
We study the evolutionary Prisoner's Dilemma on two social networks obtained
from actual relational data. We find very different cooperation levels on each
of them that can not be easily understood in terms of global statistical
properties of both networks. We claim that the result can be understood at the
mesoscopic scale, by studying the community structure of the networks. We
explain the dependence of the cooperation level on the temptation parameter in
terms of the internal structure of the communities and their interconnections.
We then test our results on community-structured, specifically designed
artificial networks, finding perfect agreement with the observations in the
real networks. Our results support the conclusion that studies of evolutionary
games on model networks and their interpretation in terms of global properties
may not be sufficient to study specific, real social systems. In addition, the
community perspective may be helpful to interpret the origin and behavior of
existing networks as well as to design structures that show resilient
cooperative behavior.Comment: Largely improved version, includes an artificial network model that
fully confirms the explanation of the results in terms of inter- and
intra-community structur
An optically stimulated superconducting-like phase in K3C60 far above equilibrium Tc
The control of non-equilibrium phenomena in complex solids is an important
research frontier, encompassing new effects like light induced
superconductivity. Here, we show that coherent optical excitation of molecular
vibrations in the organic conductor K3C60 can induce a non-equilibrium state
with the optical properties of a superconductor. A transient gap in the real
part of the optical conductivity and a low-frequency divergence of the
imaginary part are measured for base temperatures far above equilibrium Tc=20
K. These findings underscore the role of coherent light fields in inducing
emergent order.Comment: 40 pages, 23 figure
Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation
BACKGROUND: Recent evidence suggests that endogenous arginase activity potentiates airway responsiveness to methacholine by attenuation of agonist-induced nitric oxide (NO) production, presumably by competition with epithelial constitutive NO synthase for the common substrate, L-arginine. Using guinea pig tracheal open-ring preparations, we now investigated the involvement of arginase in the modulation of neuronal nitric oxide synthase (nNOS)-mediated relaxation induced by inhibitory nonadrenergic noncholinergic (iNANC) nerve stimulation. METHODS: Electrical field stimulation (EFS; 150 mA, 4 ms, 4 s, 0.5 – 16 Hz)-induced relaxation was measured in tracheal preparations precontracted to 30% with histamine, in the presence of 1 μM atropine and 3 μM indomethacin. The contribution of NO to the EFS-induced relaxation was assessed by the nonselective NOS inhibitor L-NNA (0.1 mM), while the involvement of arginase activity in the regulation of EFS-induced NO production and relaxation was investigated by the effect of the specific arginase inhibitor nor-NOHA (10 μM). Furthermore, the role of substrate availability to nNOS in EFS-induced relaxation was measured in the presence of various concentrations of exogenous L-arginine. RESULTS: EFS induced a frequency-dependent relaxation, ranging from 6.6 ± 0.8% at 0.5 Hz to 74.6 ± 1.2% at 16 Hz, which was inhibited with the NOS inhibitor L-NNA by 78.0 ± 10.5% at 0.5 Hz to 26.7 ± 7.7% at 8 Hz (P < 0.01 all). In contrast, the arginase inhibitor nor-NOHA increased EFS-induced relaxation by 3.3 ± 1.2-fold at 0.5 Hz to 1.2 ± 0.1-fold at 4 Hz (P < 0.05 all), which was reversed by L-NNA to the level of control airways in the presence of L-NNA (P < 0.01 all). Similar to nor-NOHA, exogenous L-arginine increased EFS-induced airway relaxation (P < 0.05 all). CONCLUSION: The results indicate that endogenous arginase activity attenuates iNANC nerve-mediated airway relaxation by inhibition of NO generation, presumably by limiting L-arginine availability to nNOS
Cardiac Tissue Engineering: Implications for Pediatric Heart Surgery
Children with severe congenital malformations, such as single-ventricle anomalies, have a daunting prognosis. Heart transplantation would be a therapeutic option but is restricted due to a lack of suitable donor organs and, even in case of successful heart transplantation, lifelong immune suppression would frequently be associated with a number of serious side effects. As an alternative to heart transplantation and classical cardiac reconstructive surgery, tissue-engineered myocardium might become available to augment hypomorphic hearts and/or provide new muscle material for complex myocardial reconstruction. These potential applications of tissue engineered myocardium will, however, impose major challenges to cardiac tissue engineers as well as heart surgeons. This review will provide an overview of available cardiac tissue-engineering technologies, discuss limitations, and speculate on a potential application of tissue-engineered heart muscle in pediatric heart surgery
Resolution of the stochastic strategy spatial prisoner's dilemma by means of particle swarm optimization
We study the evolution of cooperation among selfish individuals in the
stochastic strategy spatial prisoner's dilemma game. We equip players with the
particle swarm optimization technique, and find that it may lead to highly
cooperative states even if the temptations to defect are strong. The concept of
particle swarm optimization was originally introduced within a simple model of
social dynamics that can describe the formation of a swarm, i.e., analogous to
a swarm of bees searching for a food source. Essentially, particle swarm
optimization foresees changes in the velocity profile of each player, such that
the best locations are targeted and eventually occupied. In our case, each
player keeps track of the highest payoff attained within a local topological
neighborhood and its individual highest payoff. Thus, players make use of their
own memory that keeps score of the most profitable strategy in previous
actions, as well as use of the knowledge gained by the swarm as a whole, to
find the best available strategy for themselves and the society. Following
extensive simulations of this setup, we find a significant increase in the
level of cooperation for a wide range of parameters, and also a full resolution
of the prisoner's dilemma. We also demonstrate extreme efficiency of the
optimization algorithm when dealing with environments that strongly favor the
proliferation of defection, which in turn suggests that swarming could be an
important phenomenon by means of which cooperation can be sustained even under
highly unfavorable conditions. We thus present an alternative way of
understanding the evolution of cooperative behavior and its ubiquitous presence
in nature, and we hope that this study will be inspirational for future efforts
aimed in this direction.Comment: 12 pages, 4 figures; accepted for publication in PLoS ON
Patterns of wood carbon dioxide efflux across a 2,000-m elevation transect in an Andean moist forest
During a 1-year measurement period, we recorded the CO2 efflux from stems (RS) and coarse woody roots (RR) of 13–20 common tree species at three study sites at 1,050, 1,890 and 3,050 m a.s.l. in an Andean moist forest. The objective of this work was to study elevation changes of woody tissue CO2 efflux and the relationship to climate variation, site characteristics and growth. Furthermore, we aim to provide insights into important respiration–productivity relationships of a little studied tropical vegetation type. We expected RS and RR to vary with dry and humid season conditions. We further expected RS to vary more than RR due to a more stable soil than air temperature regime. Seasonal variation in woody tissue CO2 efflux was indeed mainly attributable to stems. At the same time, temperature played only a small role in triggering variations in RS. At stand level, the ratio of C release (g C m−2 ground area year−1) between stems and roots varied from 4:1 at 1,050 m to 1:1 at 3,050 m, indicating the increasing prevalence of root activity at high elevations. The fraction of growth respiration from total respiration varied between 10 (3,050 m) and 14% (1,050 m) for stems and between 5 (1,050 m) and 30% (3,050 m) for roots. Our results show that respiratory activity and hence productivity is not driven by low temperatures towards higher elevations in this tropical montane forest. We suggest that future studies should examine the limitation of carbohydrate supply from leaves as a driver for the changes in respiratory activity with elevation
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